Banca de QUALIFICAÇÃO: MALISLENE LUCAS DE ARAUJO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : MALISLENE LUCAS DE ARAUJO
DATA : 06/10/2026
HORA: 13:30
LOCAL: Qualificação da Malislene Quarta-feira, 30 de setembro · 1:30 – 2:30pm Fuso horário: America/Cuiaba
TÍTULO:

Pesticide Exposure and Risk of Neurological Alterations Related to Autism Spectrum Disorder: Biological Evidence from a Systematic Review

PALAVRAS-CHAVES:

Neurodevelopment; Genetic factors; Epigenetic mechanisms; Neurochemistry; Environmental exposure.

PÁGINAS: 72
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
SUBÁREA: Psicologia do Desenvolvimento Humano
RESUMO:

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication, restricted and repetitive behavioral patterns, and sensory alterations, with a globally increasing prevalence. This study presents a synthesis of evidence from two systematic literature reviews on ASD. The first article investigated the biological mechanisms associated with ASD, focusing on genetic, epigenetic, neurochemical, immunological, metabolic, and nutritional factors that influence core neurodevelopmental processes such as neurogenesis, synaptic plasticity, and excitatory-inhibitory balance. The second article analyzed the relationship between pesticide exposures and neurological alterations related to ASD, highlighting the role of environmental chemical agents as modulators of neurodevelopmental risk, especially during critical gestational periods. Both studies rigorously followed PRISMA guidelines, with searches in Web of Science, ScienceDirect, and SciELO, covering publications from 2005 to 2025, and included peer-reviewed original articles while excluding narrative reviews, editorials, case reports, and unpublished theses. The results indicate that ASD has a multifactorial etiology in which biological mechanisms interact with environmental factors, with pesticides being the main chemical compounds related to observed neurobiological alterations. The discussion emphasizes that an integrated understanding of these mechanisms is essential not only to expand knowledge on the neurobiological basis of ASD but also to guide targeted clinical interventions, including early diagnostic strategies, individualized therapeutic approaches, and cognitive and behavioral stimulation programs. Additionally, the findings underscore the need for public policies promoting environmental prevention, reducing exposure to neurotoxic agents during critical developmental periods, as well as initiatives for social inclusion and adaptive education for individuals with ASD. The final considerations highlight that advancing the understanding of the interactions among genetics, epigenetics, and environmental factors can contribute to the development of early biomarkers, the formulation of nutritional and environmental recommendations, and the establishment of integrated public health guidelines, thereby enhancing well-being and quality of life for the affected population.

MEMBROS DA BANCA:
Presidente - 131919001 - RAIMUNDO NONATO CUNHA DE FRANCA
Interna - 136121002 - ALESSANDRA REGINA BUTNARIU
Externo à Instituição - GESSÉ DUQUE FERREIRA DE OLIVEIRA - UFPA